Cosmelan®

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The #1 depigmentation method in the world

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The Evolution of

Cosmelan®

A depigmenting method that fully removes spots of melanic origin and prevents their reappearance, achieving a short-term outcome while keeping the hyperpigmentation under control for a long-lasting outcome.

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More than 1 million patients

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Dual action with unique efficacy

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Excellent clinical results

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Highpatient satisfaction

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Wideprofessional trust

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Patent that endorses its innovation

DEPIGMENTATION ACTION

Total melanin test in melanocyte culture stimulated with L-Turosibe and treated with cosmelan®

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melanin
synthesis

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Encapsulated complex

A flexible, encapsulated complex containing two active ingredients with antioxidant properties: apigenin and phloretin. Its three-dimensional structure provides stability to the active ingredients.

Less Melanin antiaging action
Autophagy
Auto-regulating mechanism for the overproduction of melanin.
Epigenetics
Reduction of the gene expression of enzymes that activate melanogenesis.
Increase in collagen and elastin synthesis.

Reduction of metalloprotei- nases (MMPs), enzymes that degrade collagen.

X3

Autophagy
marker

Less Melanin
Autophagy
Auto-regulating mechanism for the overproduction of melanin.
Epigenetics
Reduction of the gene expression of enzymes that activate melanogenesis.

X3

Autophagy
marker

antiaging action
Increase in collagen and elastin synthesis.

Reduction of metalloprotei- nases (MMPs), enzymes that degrade collagen.

EFFICACY OF cosmesome®

We have proven the efficacy of the depigmentation action of the complex encapsulated by a conduction system made up of apigenin and phloretin.

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Patent that endorses its innovation

Own molecular design. Its 3D conformational and molecular structure offers high safety and specificity in inhibiting the enzyme tyrosinase’s activity.

DEPIGMENTATION ACTION

EFFICACY OF melaphenone®

Its efficacy in inhibiting enzyme tyrosinase is proven by regulating melanin synthesis.

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OXIDATIVE ANTI-STRESS ACTION

They are subjected to oxidative stress in a test conducted on fibroblasts cultures that are applied by a fluorogenic probe.

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control + oxidative stress
In the control subject to oxidative stress, we observe an increase in fluorescence (mainly in the nucleus), which is related to cell damage.

melaphenone® + oxidative stressIn the fibroblasts culture subject to oxidative stress and treated with melaphenone®,we observe a lower signal, similar to the initial state, which evidences the protective effect of melaphenone® and its antioxidant capacity.

ANTI-GLYCATION ACTION

In real-time 3D microscopy we can see that glycation causes cell damage involving the typical morphological changes of cell death (control).

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We have demonstrated an anti-glycation action in cells treated with melaphenone®, as cell activity and its integrity are maintained. As a result, the active ingredient protects against the damage induced by glycation.

How does it work?

cosmelan® formula is a unique combination of active ingredients of proven efficacy that acts on the entire process of spot formation to remove the accumulation of melanin and inhibit the formation of new spots.

Spot formation
process

Melanin built up on the surface forming visible spots.

Melanin rise to the uppermost skin layers and darkening of the pigment.

Transfer of the melanin formed through the melanocyte dendrites to the epidermal cells.

Stimulation of melanin synthesis by multiple factors (sun radiation, genetic predisposition, hormonal changes, inflammatory processes, etc.).

Alteration of the dermoepidermal barrier. The melanin formed descends to the dermis.

Structural changes in collagen and elastin (solar elastosis).

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action mechanisms
cosmelan®

Acceleration of epidermis renewal in order to remove melanin accumulation by means of an exfoliating action.

Reduced amount of the melanin formed, decreasing the intensity of the spot.

Elimination of melanin in keratinocytes via an autophagy action mechanism.

Block of melanin transfer from the melanocyte to the keratinocyte, avoiding migration of the pigment to the uppermost layers.

Melanin autophagy.

Reduction in melanin synthesis inside melanocytes, thanks to tyrosinase’s inhibiting action.

Reduction of the gene expression of enzymes that activate melanogenesis.

Increase in collagen and elastin synthesis.

Protection of the dermis’ structural collagen due to the reduction in metaloproteinases (MMPs).

mesoestetic®

The Evolution of Cosmelan® Pack

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mesoestetic®

The Evolution of Cosmelan® Pack

$ 370
$ 296

The world’s leading depigmenting method.

Cosmelan® is a depigmenting method that fully removes spots of melanic origin and prevents their reappearance, achieving a short-term outcome while keeping the hyperpigmentation under control for a long-lasting outcome for all skin types and phototypes.

The cosmelan® formula is a unique combination of active ingredients of proven efficacy that acts on the entire process of spot formation to remove the accumulation of melanin and inhibit the formation of new spots.

This method is a combination of in-office treatment and home treatment with synergistic action that ensures:

  • Higher depigmenting efficacy
  • Greater comfort during treatment
  • Lower risk of repigmentation

Monitoring the home guideline is essential to achieving the depigmenting objective in the short and long term.

Evolution of the professional depigmentation method:

  • Formula evolution
  • Clinical protocol evolution
  • Patented molecule* and vehiculation system**
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mesoestetic®

The Evolution of Cosmelan® Pack

$ 370
$ 370
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Webinar | The Evolution of Cosmelan Q&A

FAQ´s

It can be done throughout the year; however, it is important to always maintain constant photoprotection and constant professional supervision.

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Elevate Your Skincare Experience with Cosmelan

At Xtetic, we believe that everyone deserves to feel confident in their skin. We offer more than just a product – we provide a solution that empowers your patients to embrace their natural beauty. Join us on this journey to radiant skin.